Efficacy and Safety of Growth Hormone Treatment in Children Small for Gestational Age

Inclusion Criteria: * Born small for gestational age (SGA) due to intrauterine growth retardation (IUGR) defined as birth length and/or weight below P10 * Chronological age at least 4 years old until bone age maturation of maximum 12 years for girls and maximum 13,5 for boys at time of inclusion in the study * Insufficient catch-up growth (height lesser than or equal to -2.5 SDS for chronological age * Normal response to GH stimulation test (greater than 10 ng/mL) Exclusion Criteria: * Diabetes * Growth retardation associated with infections severe chronic diseases (including chromosomal anomaly or nutritional disorders) * Treatment with any medical product (anabolic drugs, sex steroids, etc.) which may interfere with GH effects * History or presence of severe disease that could interfere with GH treatment/participation in the trial, e.g. active malignancy * Previous or ongoing growth hormone therapy