Hypericum vs Fluoxetine for Mild to Moderate Adolescent Depression

Inclusion Criteria: * Signed informed consent * Adolescents aged 12 to 18 years * Patients meeting the criteria for mild to moderate depression according to the DSM-IV scale * Physical and laboratory examination at baseline compatible with study criteria * ECG at baseline compatible with study criteria * Score of at least 40 on the Children's Depression Rating Scale - Revised (CDRS-R) at baseline Exclusion Criteria: * Patients with psychosis, bi-polar disease, schizophrenia or significant developmental disorder * Patients with epilepsy * Patients with a history of alcohol or substance abuse in the past year * Initiation of psychotherapy or behavioral therapy in the 2 months prior to screening or during the study. * Patients who have previously failed to respond to SSRI's or SRNI's * Patients who have been treated with antidepressants within 2 weeks of screening (4 weeks if fluoxetine) * Patients with a contraindication to taking either Remotiv or fluoxetine or taking medication contraindicated when taking Remotiv or fluoxetine