Systemic, Intrapulmonary and Pleural Inflammatory Reaction in Patients Undergoing Thoracic Surgery

University Hospital, Basel, Switzerland15 enrolled

Overview

Inflammatory reaction in different compartments of the body may have a negative effect on outcome. This study assesses the inflammatory reaction systemically, intrapulmonary and intrapleural by measuring different cytokines. Patients with lung cancer undergoing lobectomy or segmentectomy are included in the study. Hypothesis: The inflammatory reaction in the pleural space is high compared to the systemic and intrapulmonary ones.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Lung Neoplasms

Eligibility

Sex: ALLMin age: 20 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * elective lobectomy * elective segmentectomy * 20-90 years * informed consent given Exclusion Criteria: * emergency operations * pneumonectomy

Locations (1)

University Hospital Basel

Basel, Switzerland

Outcomes

Primary Outcomes

Cytokine levels in blood, bronchial lavage fluid and pleural fluid

Time frame: 2 years

Correlation between cytokine levels and pulmonary morbidity

Time frame: 2 years

Secondary Outcomes

Comparison of this collective with transthoracic esophagectomies and evaluation of the inflammatory reactions (esophageal collective registered:NCT00512265)

Time frame: 4 years

Data from ClinicalTrials.gov

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