Prevention of Acute Mountain Sickness by Intermittent Hypoxia

Heidelberg University75 enrolled

Overview

Acclimatization by mountaineering prior to high altitude sojourns have shown to be effective in prevention of acute mountain sickness (AMS). The aim of this study is to investigate whether intermittent exposure to normobaric hypoxia during sleep is also effective to prevent AMS.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Acute Mountain Sickness

Interventions

Hypoxic ExposureOTHER

Sleeping in normobaric hypoxia for 14 nights at altitudes from 2500 - 3300 m prior to one night at 4500 m

Eligibility

Sex: MALEMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy Exclusion Criteria: * Altitude exposure above 2000 m 8 weeks prior or during the study

Locations (1)

Sports Medicine, University Hospital

Heidelberg, Germany

Outcomes

Primary Outcomes

incidence of acute mountain sickness

Time frame: during one night at 4500 m

Secondary Outcomes

Sleep quality

Time frame: during one night at altitude

ventilatory acclimatization

Time frame: during one night at altitude

Data from ClinicalTrials.gov

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