PH-797804 is a potent ant-inflammatory drug that may reduce the inflammation that is associated with COPD. PH-797804 will be dosed to patients with COPD to evaluate its potential safety and efficacy profile in COPD.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
230
Safety and tolerability measures (AEs, 12-lead ECG, lab safety) during 6 weeks of treatment and up to 2 weeks post treatment.
Time frame: 6 weeks
Spirometry measures during 6 weeks of treatment and up to 2 weeks post treatment.
Time frame: 6 weeks
Peak expiratory flow rate.
Time frame: 6 weeks
Blood sample for pharmacogenomics
Time frame: 6 weeks
Blood sample for pharmacokinetics
Time frame: 6 weeks
Rescue bronchodilator usage.
Time frame: 6 weeks
Dyspnea index scores.
Time frame: 6 weeks
Global impression of change (patient and clinician).
Time frame: 6 weeks
Symptom scores.
Time frame: 6 weeks
Blood sample for biomarkers
Time frame: 6 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Pfizer Investigational Site
La Plata, Buenos Aires, Argentina
Pfizer Investigational Site
Buenos Aires, Buenos Aires F.D., Argentina
Pfizer Investigational Site
Buenos Aires, Buenos Aires F.D., Argentina
Pfizer Investigational Site
Ciudad Autonoma de Buenos Aires (caba), Buenos Aires F.D., Argentina
Pfizer Investigational Site
Rosario, Santa Fe Province, Argentina
Pfizer Investigational Site
Camperdown, New South Wales, Australia
Pfizer Investigational Site
Daw Park, South Australia, Australia
Pfizer Investigational Site
Nedlands, Western Australia, Australia
Pfizer Investigational Site
Vancouver, British Columbia, Canada
Pfizer Investigational Site
Winnipeg, Manitoba, Canada
...and 35 more locations