Topical Avastin for Treatment of Corneal Neovascularization

Inclusion Criteria: * Male or female, at least 18 years of age * Clinical stable corneal neovascularization (as defined above) * Ability to understand and provide informed consent to participate in this study and willingness to follow study instructions and likely to complete all required visits. * All female patients of childbearing potential will be excluded. A female is considered to be of childbearing potential unless she is postmenopausal and without menses for 12 months or without a uterus and/or both ovaries. Exclusion Criteria: * Current or recent (≤ 1 month) systemic corticosteroid therapy or periocular corticosteroid injections to the study eye * Current or recent (≤ 3 months) intravitreal drug injection to the study eye; recent (≤ 1 month) change in dose and frequency of topical steroids and/or non-steroidal anti-inflammatory agents * Uncontrolled hypertension defined as systolic blood pressure of ≥ 150 mmHg or diastolic blood pressure of ≥ 90 mmHg; history of a thromboembolic event, including myocardial infarction or cerebral vascular accident * Patients age 75 or older; history of renal abnormalities * Recent (≤ 3 months ) or planned surgery * History of coagulation abnormalities, including end stage liver disease or current anticoagulation medication other than aspirin (warfarin, heparin, enoxaparin, or similar anticoagulant agent) * All female patients of childbearing potential (a female is considered to be of childbearing potential unless she is postmenopausal and without menses for 12 months or without a uterus and/or both ovaries) * Any condition (including language barrier) that precludes patient's ability to comply with study requirements including completion of study