Regulation of Inflammatory Parameters by Telmisartan in Hypertensive Patients

Ludwig-Maximilians - University of Munich56 enrolled

Overview

A number of studies have shown that certain blood-pressure medications such as ACE-inhibitors and angiotensin-II-receptor blockers (ARB) can reduce the incidence of diabetes mellitus type 2. This protocol will evaluate whether inflammatory mechanisms mediate this effect. The investigators therefore will investigate the effect of telmisartan, a potent ARB, on lipid metabolism, glucose metabolism and inflammation in patients with the metabolic syndrome. Specific parameters will be tested before treatment and after 3 months of treatment. Placebo will be compared to 2 different doses of telmisartan per day.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Enrollment

Conditions

Hypertension Metabolic Syndrome Hypertriglyceridemia

Interventions

Eligibility

Sex: ALLMin age: 19 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Abd. obesity (BMI\>25kg/m²) and waist circumference ≥95cm (men),≥80cm (women) * Blood pressure ≥130 mmHg (systolic) and/or ≥85 mmHg (diastolic) * Triglycerides 150-400 mg/dl * Normal stress test * Normal carotid ultrasound * Normal fundoscopy Exclusion Criteria: * Diabetes mellitus * Secondary cause for insulin resistance * LDL-cholesterol \>190 mg/dl * Atherosclerotic disease * Blood pressure \>160 mmHg (systolic) and/or \>100 mmHg (diastolic) * Regular alcohol consumption (\>30 g/day) * Contraindication against telmisartan * Antihypertensive medications * Lipid lowering therapy * Malignancy * Pregnancy or Lactation * Women without adequate contraception

Locations (2)

Center for Cardiovascular Research, University Berlin

Berlin, Germany

Med. Dept. 2, University Munich

Munich, Germany

Outcomes

Primary Outcomes

change in IL-6

Time frame: 14 weeks

Secondary Outcomes

change in fasting lipids;

Time frame: 14 weeks

change in postprandial lipid metabolism

Time frame: 14 weeks

change in inflammatory parameters

Time frame: 14 weeks

change in glucose metabolism

Time frame: 14 weeks