Does Inhaled Busedonide or Fluticasone Impair Adrenal Function?

HaEmek Medical Center, Israel50 enrolled

Overview

Inhaled corticosteroids are largely used in patients with asthma or chronic obstructive lung diseases. The purpose of this study is to determine if the use of inhaled corticosteroids is associated with suppression of endogenous cortisol production, as seen in patients treated with pharmacologic doses of oral or parenteral steroids.

The normalcy of the hypothalmic-pituitary-adrenal (HPA) axis of enrolled subjects will be assessed by low dose (1mcg) corticotropin (ACTH)stimulation test. Serum cortisol levels will be measured before , 30 minutes and 60 minutes after 1 mcg ACTH intravenous injection.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Adrenal Insufficiency

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients receiving inhaled busedonide or fluticasone at daily dose of 200-800 mcg ' for at least 4 weeks Exclusion Criteria: * patients receiving any corticosteroid therapy, except inhaled busedonide or fluticasone.

Locations (1)

Endocrine Institute, Haemek medical Center

Afula, Israel

Outcomes

Primary Outcomes

stimulated serum cortisol levels

Time frame: within 30 days of treatment

Data from ClinicalTrials.gov

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