Schizophrenia and PTSD Project: Health, Interventions, and Risk/Resilience Evaluation(SAPPHIRE Study)

Durham VA Medical Center400 enrolled

Overview

We propose to establish a database characterizing the presence or absence of comorbid PTSD in veterans with schizophrenia or schizoaffective disorder (SAD) receiving services at the Durham VA Medical Center. In addition to the evaluation of PTSD symptoms in veterans with schizophrenia or SAD, this database will facilitate the investigation of a number of additional specific research questions relevant to veterans with psychotic disorders.

See brief summary

Study Type

OBSERVATIONAL

Enrollment

400

Conditions

Schizophrenia PTSD

Eligibility

Sex: ALLMin age: 18 YearsMax age: 72 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. 18-72 years of age, any ethnic group, either sex. 2. Diagnostic and Statistical Manual, Fourth Edition (DSM-IV) diagnosis of schizophrenia or schizoaffective disorder. 3. Ability to fully participate in the informed consent process, or have a legal guardian able to participate in the informed consent process. Exclusion Criteria: 1. Unstable current medical or neurological illness. 2. Significant suicidal or homicidal ideation. 3. Pregnant women or women who could be pregnant.

Locations (1)

Durham VAMC

Durham, North Carolina, United States

Outcomes

Primary Outcomes

Brief Assessment of Cognition in Schizophrenia (BACS)

The Brief Assessment of Cognition in Schizophrenia (BACS) includes brief assessments of executive functions, verbal fluency, attention, verbal memory, working memory and motor speed. Z-scores are calculated from composite scores. Higher z-scores are indicative of better cognitive performance, lower z-scores are indicative of lower cognitive performance. Range of z-scores anticipated to be between -3 and 3.

Time frame: Visit 1

Data from ClinicalTrials.gov

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