Efficacy Study of Intramuscular or Intracoronary Injection of Autologous Bone Marrow Cells to Treat Scarred Myocardium

University Hospitals, Leicester63 enrolled

Overview

The purpose of this study is to determine whether the administration of patient's own bone marrow cells into scar areas of the heart, can improve the contractile function of these areas.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Myocardial Infarct Bone Marrow Cells

Interventions

ControlPROCEDURE

Coronary artery bypass grafting without bone marrow cells injection

Intramuscular administration of bone marrow cellsPROCEDURE

Coronary artery bypass grafting, and intramuscular administration of bone marrow cells into myocardial scar

Intracoronary administration of bone marrow cellsPROCEDURE

Coronary artery bypass grafting, and intracoronary administration of bone marrow cells into myocardial scar

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients undergoing elective CABG * chronic irreversible myocardial scar * coronary vessel supplying the scar must be amenable to bypass grafting Exclusion Criteria: * significant valvular heart diseases * major organ failures, eg. heart, liver, renal etc * pre-existing bone marrow conditions

Locations (1)

University Hospitals Leicester

Leicester, Leicestershire, United Kingdom

Outcomes

Primary Outcomes

Contractile function of treated scar areas

Time frame: 6 months

Secondary Outcomes

Global left ventricular functions

Time frame: 6 months

Data from ClinicalTrials.gov

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