Comparison of Two Multi-Purpose Solution and Lens Material Combinations on Corneal Barrier Function

Inclusion Criteria: * At least 18 years of age. * Understand your rights as a research subject and give written informed consent by signing the Informed Consent Form, Subject Bill of Rights, and Patient Authorization for Use and Release of Health and Research Study Information (HIPAA form). * Be likely to finish the entire study, understand the study instructions, and be willing to follow the instructions. * Contact lens prescription between +4.00 D to -9.00 D (spherical equivalent). * Best correctable visual acuity of at least 20/40 in each eye. * Willing to de-adapt (do not wear) from habitual contact lenses for periods of three days prior to barrier function determination. * Possess a functional spectacle prescription to allow adequate vision during the de-adaptation and barrier function determination periods. * No known ocular or systemic allergies, which may interfere with contact lens wear. * No known systemic disease, or need for medication that may interfere with contact lens wear (i.e. antihistamines, beta-blockers, steroids). Exclusion Criteria: * Subjects demonstrating any medical condition that may affect the results of this study SHOULD NOT be enrolled. The following are specific conditions that exclude subjects from enrollment in this study. * Eye (ocular) or systemic allergies that may interfere with contact lens wear. * Less than one month successful, full time (defined as more than 8 hours per day, and more than 5 days per week) soft lens wear. * Systemic disease or uses of medication, which may interfere with contact lens wear. * Clinically significant corneal swelling (greater than grade 3 or 4 on a 0-4 scale), corneal blood vessel growth) (vascularization), corneal staining, bulbar redness, tarsal redness, or any other abnormality of the cornea that may cause unsafe contact lens wear. * Any active ocular infection. * Prior corneal refractive surgery (i.e., LASIK, PRK, etc). * Have used medications within 24 hours of study entry or have an ongoing need to use ocular medication. * Are taking part in any other study or have taken part in a study within the last 14 days * Have a medical condition that your study eye doctor thinks may make it not appropriate for you to participate in this study. * Are pregnant, or anticipate becoming pregnant during the course of this study.