Chlamydia and Mycoplasma in Coronary Artery Disease

Hospital de Base138 enrolled

Overview

To test the association between anti-Chlamydia serum titers and anti-Mycoplasma antibodies with Acute Coronary Syndromes.

One hundred and twenty-six patients were divided into 4 groups: Acute Coronary Syndrome with ST-elevation, Non-ST-elevation, stable coronary artery disease, and individuals without coronary disease. Anti-Chlamydia and anti-Mycoplasma IgG antibodies were measured at baseline and after 6 months.

Study Type

OBSERVATIONAL

Enrollment

138

Conditions

Atherosclerosis Coronary Artery Disease Chlamydia Infections Mycoplasma Infections

Interventions

blood sample analysis - mycoplasma and chlamydia antibodiesOTHER

Anti-Chlamydia and anti-Mycoplasma IgG antibodies were measured by indirect immunofluorescence at baseline (24 hours of hospitalization) and after 6 months (follow-up).

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age \>18 yrs * Males and females * Agreed to sign the informed consent Exclusion Criteria: * Refusal to sign the informed consent * Follow-up not possible * For the "acute" groups, time between the pain beginning and randomization \>24 hours * Active infections * Use of antimicrobial agents within the last 30 days * End-stage diseases with life expectancy \<6 months

Outcomes

Primary Outcomes

Test the hypothesis that patients with acute coronary syndromes have higher levels of Chlamydia pneumonia and Mycoplasma pneumonia antibodies in comparison with patients with stable coronary artery disease or controls.

Time frame: 6 months

Data from ClinicalTrials.gov

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