Over the past century life expectancy has risen rapidly. As a result, the proportion of elderly people continues to grow. Elderly people probably have an impaired regulation of energy balance (energy intake versus energy expenditure) whereby the underlying physiological mechanisms are not fully understood. The first objective of this study is to provide further evidence for an age-related failure to regulate energy balance in elderly. If the hypothesis of impaired regulation of energy balance in elderly is confirmed then the second objective becomes to elucidate the underlying physiological mechanisms of the age-related failure to regulate energy intake in elderly.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
32
The experiment can be divided in 3 phases, namely (1) run-in phase, (2) energy restriction phase and (3) ad libitum food intake phase. Thus, for all participants the experiment consists of three subsequent phases.
Wageningen University, Division of Human Nutrition
Wageningen, Gelderland, Netherlands
Energy Intake Compensation
To assess energy intake compensation, we will assess average energy intake during the ad libitum food intake phase - which is the period after energy restriction- in young men and compare this to average energy intake in older men. Average energy intake is assessed by measuring total megajoule of energy intake during nine days of the ad lib phase, and then divide it by nine (MJ/day)
Time frame: Average intake of energy during ad lib phase (9 days)
Appetite/Satiety Hormones and Questionnaires
Time frame: Before and after the energy restriction period.
Gastrointestinal Function
Time frame: Before and after the energy restriction period
Resting Energy Expenditure, Body Composition and Body Weight
Time frame: Before and after the energy restriction period
Expression of Genes Involved in Energy Metabolism
Time frame: Before and after the energy restriction period.
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