Effect of a Probiotic, Lactobacillus FARCIMINIS, in Diarrhea Predominant IBS Patients

Assistance Publique - Hôpitaux de Paris60 enrolled

Overview

Probiotics may improve symptoms in IBS patients. The aim of this study is to test the efficacy of Lactobacillus FARCIMINIS in diarrhea predominant IBS patients according to Rome III criteria.

The aim of this study is to test the efficacy of Lactobacillus FARCIMINIS in diarrhea predominant IBS patients according to Rome III criteria.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Irritable Bowel Syndrome

Interventions

Lactobacillus FARCIMINISDIETARY_SUPPLEMENT

10.10 UFC of lactobacillus FARCIMINIS

placebo (starch)DIETARY_SUPPLEMENT

Once daily

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diarrhea predominant IBS * Less than 5-year duration * Pain intensity between 2 and 7 on VAS Exclusion Criteria: * Celiac disease * Antibiotic treatment within the 1-month period preceding inclusion * Digestive organic disease * Any severe non digestive organic disease

Locations (1)

Hopital Louis Mourier, GI Unit

Colombes, Île-de-France Region, France

Outcomes

Primary Outcomes

Overall subject's assessment

Time frame: 4 weeks

Secondary Outcomes

Decrease in abdominal pain, stool form and consistency, modifications in intestinal permeability, modification in fecal serine protease activity, modifications in interleukin seric concentrations

Time frame: 4 weeks

Data from ClinicalTrials.gov

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