Treatment of Polytraumatisms With Corticoids

Nantes University Hospital150 enrolled

Overview

Interest of treatment of polytraumatisms with corticoids (hydrocortisone) for patient with relative adrenocortical insufficiency on frequency of nosocomial infection, and hemodynamic complications and organs injuries.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

150

Conditions

Polytraumatism

Interventions

hydrocortisoneDRUG

200mg/jour (solution of 48mL), Day 1 to Day 4 100mg/jour (solution of 48mL), Day 5 50mg/jour (solution of 48mL), Day 6

NaClDRUG

48mL from Day 1 to Day 6

Eligibility

Sex: ALLMin age: 15 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age superior of 15 years * Hospitalization in reanimation for polytraumatism (lesion of two organs with a vital risk) * SISS score more than 15 * Intubation for more than 48 hours. * Agreement of a family member * Patient with insurance Exclusion Criteria: * History of corticothérapies within 6 months * History of adrenocortical insufficiency. * Treatment by immunosuppressor * Immunodeficiency.

Locations (7)

CHU Bordeaux

Bordeaux, France

CHU Morvan de Brest

Brest, France

CHU Caen

Caen, France

CH La Roche Sur Yon

La Roche-sur-Yon, France

Outcomes

Primary Outcomes

Incidence of nosocomial pneumopathy: radiological, clinical and bacteriological criteria

Time frame: 28 days

Secondary Outcomes

Incidence of bacteremia, urinary infections, infections of the operatory sites, incidence of SDRA, organ dysfunction,mortality, etc.

Time frame: 28 days

Incidence of nosocomial pneumopathy

Time frame: Day 8

Data from ClinicalTrials.gov

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