A Study Comparing Multiple Doses of VI-0521 With Placebo and Their Single-agent Constituents for Treatment of Obesity in Adults

Inclusion Criteria: * 70 years of age or less with body mass index (BMI) between 30 and 45 kg/m2 * Informed Consent * Females of child-bearing potential must be using adequate contraception Exclusion Criteria: * Stroke/myocardial infarction (MI)/unstable cardiovascular disease within 6 months * Clinically significant renal, hepatic or psychiatric disease * Unstable thyroid disease or replacement therapy * Nephrolithiasis * Obesity of known genetic or endocrine origin * Participation in a formal weight loss program or lifestyle intervention * Glaucoma or elevated intraocular pressure * Pregnancy or breastfeeding * Drug or Alcohol abuse * Smoking cessation within previous 3 months or plans to quit smoking during study * Eating disorders within past year * Cholelithiasis within past 6 months * Type 2 diabetes * Previous bariatric surgery * Bipolar disorder or psychosis * Steroid hormone therapy not stable for 3 months * Systolic blood pressure \> 160 mmHg, diastolic blood pressure \> 100 mmHg