Carisbamate Retention Study (CaReS): Comparative Study on the Long Term Effectiveness, Safety and Tolerability of Carisbamate Compared to Two Other Frequently Prescribed Anti-epileptic Drugs (AEDs) in Patients With Epilepsy.

Inclusion Criteria: * Patients must weigh \>= 45 kg (\~100lbs) * established diagnosis, for at least 3 months prior to screening, of partial onset seizures, including simple partial motor, complex partial, or secondarily generalized seizures * At least 1 but no more than 120 partial onset seizures during the 3-month retrospective baseline period prior to screening * History of monotherapy AED treatment failure at at least 1 but not more than 4 AEDs in the past * Females must be postmenopausal for at least 2 years, surgically sterile, abstinent, or, if sexually active, practicing an acceptable method of birth control (eg, intrauterine device, double barrier method, male partner sterilization) before entry and throughout the study * Females must have a negative serum beta chorionic gonadotropin pregnancy test result at screening/randomization * Current AED treatment with at least 1 and no more than 2 AEDs given at a stable dose 30 days prior to screening * For adolescents (as defined by local regulations), a responsible person must be available to accompany the patient to the study center at each visit, to provide reliable information for the safety and effectiveness evaluations, and to accurately and reliably dispense the study drug as directed, if required in the opinion of the investigator. Exclusion Criteria: * Must not have a generalized epileptic syndrome, primary generalized seizures, atonic seizures, typical or atypical absence seizures nor only simple partial type seizures with manifestations other than motor symptoms (i.e, simple partial sensory) * No history of unprovoked status epilepticus in the last 6 months prior to screening nor history of Lennox-Gastaut or West Syndrome * More than 3 days of sedative or benzodiazepine use for seizures in the 3 months months prior to screening * No clinical evidence of significant cardiac disease * ALT \> 1.5 times the upper limit of normal or total bilirubin above the upper limit of normal at screen * No history of drug-induced liver injury, diagnosis of any form of chronic liver disease, cirrhosis, or liver cancer nor positive hepatitis serology as determined by multiantigen enzyme immunoassay (EIA) * No past or current with topiramate or levetiracetam for any reason * No current use of vagal nerve stimulator * No diagnosis of psychotic disorder, bipolar disease, or major depression or other neurologic conditions, serious or medically unstable systemic disease, suicidal ideation or attempts, or homicide attempts at any time in the past 2 years * Unable to swallow solid oral dosage forms whole with the aid of water (patients may not chew, divide, dissolve, or crush the study drug) * Anyone who falls under the precautions, warnings or contraindications outlined in the local topiramate and/or local levetiracetam package insert.