Chronic Heart Failure - Cheyne Stokes Respiration - CS2 (3C-study)

University of Oslo40 enrolled

Overview

An investigation where patients with chronic heart failure and cheyne stokes respiration, treated with adapitve servo ventilator, will improve their cardiac function and quality of life.

Chronic heart failure (HF) is one of the most important public health problems in cardiovascular medicine. Several patients with chronic heart failure also has Cheyne Stokes respiration pattern. Earlier studies have shown that this respiration pattern improves with Adaptive servo ventilator. We wish to investigate wether this leads to improved cardiac function.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Heart Failure Cheyne Stokes Respiration

Interventions

ASVDEVICE

Adaptive servo ventilator

without Autoset CS2OTHER

without Autoset CS2

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Ejection fraction \<40% * NYHA class III-IV * Optimized therapy with drugs * Cheyne stokes respiration pattern \> 25% while sleeping * Age \< 85 years * clinical stability the last month before inclusion. Exclusion Criteria: * CABG less then 6 months ago * PCI treatment less then 3 months ago * Unstable angina pectoris * Acute coronary syndrome less then 3 months ago * Stroke less then 6 weeks ago * Thoracal myopathy * Advanced COPD

Locations (1)

Sykehuset ostfold Fredrikstad

Fredrikstad, Norway

Outcomes

Primary Outcomes

Ejection fraction (measured with echocardiography) and inflammatory markers

Time frame: 3 months

Secondary Outcomes

6 minutes walking test Quality of life Changes in cathecolamines Altered frequency of arrythmias

Time frame: 3 months

Data from ClinicalTrials.gov

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