Benefit of Adding Chemotherapy And/Or Modification of Radiotherapy Schedule for Advance Nasopharyngeal Carcinoma (T3-4N0-1M0)

Inclusion Criteria: * Undifferentiated or non-keratinizing carcinoma * Tumor staged as T3-4 AND N0-1 * No evidence of distant metastasis (M0) * Performance status: 0-2 * Marrow: WBC \>= 4 and platelet = 100 * Renal: creatinine clearance = 60 * Informed consent Exclusion Criteria: * WHO type I squamous cell carcinoma or adenocarcinoma * Age \>= 70 * Palliative intent or tumor extent mandating AP opposing facio-cervical fields * Prior malignancy except adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, or other cancer for which the patient has been disease-free for 5 years * Previous radiotherapy (except non-melanomatous skin cancers outside the intended RT treatment volume * Previous chemotherapy * Patient is pregnant or lactating