Carbachols Headache-inducing Effect and Changes in Cerebral Blood Flow in Migraine Patients

Danish Headache Center12 enrolled

Overview

The purpose of this study is to test if carbachol infusion induces headache in migraine subjects as well as intra- and extra-cerebral vasodilatation.

To test if infusion of Carbachol induces headache in 12 migraine subjects as well as intra- and extra-cerebral vasodilatation in a double-blinded study

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Headache

Interventions

CarbacholDRUG

3 microgram per kg bodyweight infused intravenously

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Migraine without aura * Weight 50-100 kg Exclusion Criteria: * Other significant diseases * Migraine 5 days prior to experiment

Locations (1)

Danish Headache Center

Glostrup Municipality, Denmark

Outcomes

Primary Outcomes

Headache response after Carbachol infusion

Time frame: 1 day after infusion

Data from ClinicalTrials.gov

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