Postpartum Thyroid Measures and Mood

Oklahoma State University Center for Health Sciences75 enrolled

Overview

Women with abnormal serum thyroid antibody levels or abnormal TSH and/or T4 values are more likely than their normal counterparts to have higher scores on a common postpartum depression screening test.

This small pilot study was an attempt to corroborate a relationship between quantified mood and thyroid measures, using the numerical scores obtained from a common depression screen, the Edinburgh Postnatal Depression Scale (EPDS), as a continuum. Mood scores were compared with presence of thyroid autoantibodies and plasma concentrations of free T4 and TSH.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Postpartum Depression

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Over 18 years of age * In third trimester of pregnancy when recruited * Negative for the following drugs detected by a urine drug screen: * Amphetamines * Barbiturates * Benzodiazepines * Cocaine * Opiates * Phencyclidine metabolites (PCP), and tricyclic antidepressants * Vaginal delivery * Screened negative for major depressive disorder on the Edinburgh Postnatal Depression Scale (EPDS) at her prenatal enrollment in the study * Receiving a score of 12 or lower out of a possible 30 Exclusion Criteria: * Under age 18 * Positive for any of the following drugs: * Amphetamines * Barbiturates * Benzodiazepines * Cocaine * Opiates * Phencyclidine metabolites (PCP), and tricyclic antidepressants * Cesarean delivery * EPDS score over 12 at prenatal screening test

Locations (1)

Oklahoma State University Center for Health Sciences Houston Park Obstetrics Clinic

Tulsa, Oklahoma, United States

Outcomes

Primary Outcomes

Numerical score on the Edinburgh Postnatal Depression Scale

Time frame: seven weeks

Data from ClinicalTrials.gov

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