Pain Post Abdominal Laparoscopy Prevention With Arcoxia

Hospital Vozandez60 enrolled

Overview

To test the analgesic efficacy of etoricoxib used before a surgical procedure compared to the already known effect when administered after such a procedure. Patient will be receiving either etoricoxib or the respective placebo one hour before surgery, then two hours after those receiving the active will receive placebo and those that received placebo will be given etoricoxib. Pain score measurements will be performed sequentially. Rescue medication will be available all the time.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Laparoscopic Surgery for Appendicitis Laparoscopic Surgery for Cholecystitis Laparoscopic Surgery for Ovarian Cysts

Interventions

etoricoxib 120 mgDRUG

etoricoxib 120 mg, tablet, orally, OD

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Voluntary acceptance to participate in the study and signed the informed consent form * Age older than 18 years old and younger than 70 years * Diagnosis of appendicitis, cholecystitis or ovarian cysts suitable of laparoscopic surgery Exclusion Criteria: * Age less than 18 years or older than 70 years. * Laparoscopic procedures for diagnostic purposes. * Current use of anticoagulants. * Known hypersensitivity to etoricoxib or its components. * History of a CABG or MI (less than 1 year) * History of unstable angina (over the past six months). * Current inflammatory bowel disease. * Uncontrolled hypertension or heart failure * Renal dysfunction/impairment (creatinine clearance \< 30ml/min) * Cirrhosis or severe hepatic dysfunction * Any degree of dehydration (mild to severe)

Outcomes

Primary Outcomes

To measure the amount of rescue medication (opioid) needed to relief

Time frame: Every hour after surgery

Secondary Outcomes

To determine the overall analgesic effect using the visual analog scale (VAS)

Time frame: Every hour after surgery

Data from ClinicalTrials.gov

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