Activated White Blood Cells With ASCT for Newly Diagnosed Multiple Myeloma

DISEASE CHARACTERISTICS: * Diagnosis of multiple myeloma * Newly diagnosed disease * Durie-Salmon stage II or III disease * Measurable disease, defined by any of the following: * Measurable serum and/or urine M-protein levels documented and available prior to induction therapy * Positive serum free light chain assay * Must have completed a minimum of 3 courses of myeloma specific therapy * Candidate for autologous stem cell transplantation * Patients who have achieved a complete remission at the time of bone marrow harvest for marrow infiltrating lymphocytes (MILs) expansion are not eligible * No evidence of spinal cord compression * Diagnosis of the following cancers are not allowed: * POEMS syndrome (plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes) * Non-secretory myeloma (no measurable protein on serum free light chain assay) * Plasma cell leukemia * No amyloidosis PATIENT CHARACTERISTICS: * ECOG performance status 0-2 * Life expectancy ≥ 6 months * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective contraception during and up to day 180 * Corrected serum calcium \< 11 mg/dL and no evidence of symptomatic hypercalcemia * Total bilirubin ≤ 2.0 times upper limit of normal (ULN) * ALT ≤ 2.0 times ULN * Serum creatinine \< 2.0 mg/dL * No history of other malignancy within the past 5 years, except adequately treated basal cell or squamous cell skin cancer * No history of autoimmune disease (e.g., rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus) requiring systemic treatment * Hypothyroidism without evidence of Graves' disease or Hashimoto thyroiditis is allowed * No infection requiring treatment with antibiotics, antifungal, or antiviral agents within the past 7 days * No HIV infection * No major organ system dysfunction including, but not limited to, the following: * New York Heart Association class III or IV congestive heart failure * Pulmonary disease requiring the use of inhaled steroids or bronchodilators * Renal, hepatic, gastrointestinal, neurologic, or psychiatric dysfunction that would impair ability to participate in the study PRIOR CONCURRENT THERAPY: * See Disease Characteristics * No prior hematopoietic stem cell transplantation * At least 3 weeks since prior corticosteroids (i.e., glucocorticoids) * At least 3 weeks since prior myeloma-specific therapy * At least 4 weeks since participation in any clinical trial that involved an investigational drug or device * No concurrent therapy with any of the following: * Corticosteroids (e.g., hydrocortisone, prednisone, prednisolone, dexamethasone \[Decadron\]) * Inhaled steroids used for treatment of allergic rhinitis or pulmonary disease allowed * Thalidomide * Interferon * Growth factors, interleukins, or other cytokines (except filgrastim \[G-CSF\] as outlined in the protocol, or erythropoietin) * Cytotoxic chemotherapy agents (except cyclophosphamide for stem cell mobilization and high-dose melphalan) * Immunosuppressive drugs * Experimental therapies * Radiotherapy