This is a randomized, double-blind, placebo-controlled, multi-center, sequential cohort study in subjects with congestive heart failure (CHF) and impaired renal function who are on stable furosemide treatment (³ 40 mg daily). A total of 50 subjects will be randomized to each increasing dose level of SLV320 or placebo in a sequential fashion.
Study Type
OBSERVATIONAL
Enrollment
300
1, 2.5, 5, 10 and 20 mg twice daily and placebo group. Duration of treatment 84 days
Cystatine C
Time frame: 3 months
Sodium in urine
Time frame: 3 months
Estimated glomerular filtration rate
Time frame: 3 months
Clinical global impression
Time frame: 3 months
Body weight
Time frame: 3 months
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