Antipyretics for Preventing Recurrences of Febrile Seizures

University of Oulu231 enrolled

Overview

We wanted to find out if the early use of antipyretics is capable in preventing recurrences of febrile seizures. When a child has had his/her first febrile seizure, the parents were instructed to give him/her antipyretic medication every time when the child had a new episode of fever during two years.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

231

Conditions

Recurrence of Febrile Seizure

Interventions

Diclofenac, Paracetamol, IbuprofenDRUG

Immediately if temperature \> 38 degree Celsius, diclofenac suppository 1,5 mg/kg once or placebo suppository After eight hours, if temperature still \< 38 degree Celsius, acetaminophen mixture 15 mg/kg up to four times a day, or ibuprofen mixture 10 mg/kg up to four times a day, or placebo mixture up to four times a day as long as temperature \< 38 degree Celsius

Eligibility

Sex: ALLMin age: 3 MonthsMax age: 4 Years

Medical Language ↔ Plain English

Inclusion Criteria: * First febrile convulsion Exclusion Criteria: * Any prior convulsion or antiepileptic medication

Locations (1)

Heikki Rantala

Oulu, Finland

Outcomes

Primary Outcomes

recurrence of febrile seizure

Time frame: two years

Secondary Outcomes

we only had the primary outcome measure

Time frame: two years

Data from ClinicalTrials.gov

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