Urinary Biomarkers as Predictors on Renal Function in Congenital Hydronephrosis

University of Aarhus45 enrolled

Overview

The purpose of this study is to detect new urinary biomarkers that can be used as predictors on renal function in congenital hydronephrosis caused by unilateral ureteral obstruction (UUO) and to elucidate the pathophysiology of UUO.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Ureteral Obstruction

Eligibility

Sex: ALLMin age: 3 MonthsMax age: 15 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Children referred to surgical treatment of congenital hydronephrosis caused by ureteral obstruction. * Declining function of the hydronephrotic kidney more than 5 %, and to less than 40 % of the total renal function OR ipsilateral flank pain. Exclusion Criteria: * Bilateral hydronephrosis * Previous operation in the urinary system except operation for phimosis and other deformations of the external genital organs. * Deformations in the lower part of the ureter, bladder and urethra. Urinary stones. Reflux. Urinary tract infections \< 6 months. * Neurogenic bladder dysfunction. * GFR \< 40 % standardized to age. * Non-compliance. Linguistic difficulties.

Locations (1)

Institute of Clinical Medicine, University of Aarhus

Aarhus, Denmark

Outcomes

Primary Outcomes

Urinary cytokines

Time frame: 1 year

Data from ClinicalTrials.gov

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