The purpose of this study is to determine the maximum tolerated dose of alloreactive NK cells that can be transfused following stem cell transplant.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
1
Alloreactive NK cells will be purified by a two-step immunomagnetic selection (CD3 depletion followed by CD56 selection) using the CliniMACS device.
Indiana University Cancer Center
Indianapolis, Indiana, United States
Investigate the maximum-tolerated dose (MTD) of highly-purified alloreactive NK cells infused following haplotype-mismatched, KIR ligand-mismatched transplants in patients with refractory hematological malignancies.
Time frame: through Day 128
Assess toxicity associated with the infusion of alloreactive NK cells
Time frame: through Day 128
Assess the risk of acute and chronic GvHD following infusion of alloreactive NK cells.
Time frame: through Day 128
Assess the feasibility of multiple harvesting and purifying NK cells to the relatively high-doses.
Time frame: through Day 128
Describe the frequency and type of infections occurring within the first year following transplantation.
Time frame: through Day 128
Describe immune reconstitution following transplantation.
Time frame: through Day 128
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