Pharmacologic preconditioning by volatile anesthetics may depend on the mode of administration. The researchers hypothesize that a continuous administration in patients scheduled for CABG surgery prebypass will be less effective in terms of attenuating myocardial cell damage compared to a repetitive administration with a double wash in/wash out schedule. A control group will receive propofol as their primary anesthetic.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
50
1 MAC Sevoflurane will be given either continuously after induction of anesthesia until initiation of cardiopulmonary bypass or will be repetitively washed in and out twice before initiation of cardiopulmonary bypass.
University Hospital Schleswig-Holstein, Campus Kiel
Kiel, Germany
Myocardial cell damage as assessed by plasma levels of Troponin T
Time frame: from induction of anesthesia until hospital discharge
Length of stay on the ICU and in the hospital
Time frame: from hospital admission until hospital discharge
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