The primary purpose of this study is to evaluate the effect of food on oral LBH589 in adult patients with advanced solid tumors. This study will also evaluate the safety and efficacy of LBH589 in adult patients with advanced solid tumors
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
36
orally administered panobinostat at 20 mg twice weekly (core phase); orally administered panobinostat 45 mg twice weekly if 20 mg twice weekly was tolerated in Cycle 1 (extension phase)
Novartis Investigative Site
Los Angeles, California, United States
Novartis Investigative Site
Norwalk, Connecticut, United States
Novartis Investigative Site
Rockville, Maryland, United States
Novartis Investigative Site
Boston, Massachusetts, United States
Levels of LBH589 in the blood
Time frame: every week for the first 3 weeks
Efficacy, Safety and tolerability
Time frame: throughout study to 28 days after last treatment
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Novartis Investigative Site
Lebanon, New Hampshire, United States
Novartis Investigative Site
New York, New York, United States
Novartis Investigative Site
Madison, Wisconsin, United States
Novartis Investigative Site
Stockholm, Sweden
Novartis Investigative Site
Zurich, Switzerland