Efficacy Study of p38 Kinase Inhibitor to Treat Patients With Atherosclerosis

Inclusion Criteria: * History of documented atherosclerosis * LDL between 70 and 130 mg/dL * Patients receiving stable low- to moderate-dose statin * BMI 18-37 kg/m² * Must be able to swallow tablets * Must be able to medically tolerate the procedures, contrast medium, and medications involved Exclusion Criteria: * Statin intolerance * Renal impairment (serum creatinine \> 1.5 mg/dL) * History of chronic viral hepatitis or other liver dysfunction * Major infection requiring hospitalization or receipt of IV antibiotics due to an infection within 2 months prior to initiation of study treatment