Trial of Levetiracetam in Patients With Primary Brain Tumors and Symptomatic Seizures Who Undergo Surgery

Inclusion Criteria: * age ≥ 18 years * suspected primary brain tumor by imaging * planned bioptical or cytoreductive surgery of the tumor * symptomatic epilepsy * Karnofsky performance score ≥ 70% * women with child bearing potential must perform sufficient contraception * sufficient haematologic, hepatic and renal function by laboratory testing Exclusion Criteria: * treatment with other antiepileptic drugs other than levetiracetam in the last seven days before surgery * known allergic reaction to levetiracetam or other serious side effects * known, not tumor-induced, epilepsy * previous brain surgery * dementia * participation in another clinical trial * addiction to drugs or alcohol * pregnant or breast feeding women