Study of Varencline Effects on Cigarette Smoking Reward and Craving During a Model of Brief Quit Attempt

Inclusion Criteria: * At least 10 cigarettes/day * Interest in quitting smoking * Willgness to comply with overnight smoking abbstiennce period followed by lab smoking test Exclusion Criteria: * Pregnancy * Axis I psychiatric disorder which require treatment with psychoactive medication and would make study compliance difficult. * Clinically significant medical condition in opinion of study clinician * Drug or alcohol dependence inlast 12 months * Use of other smoking cessation medications ot treatment progams in last 2 months