To compare the effect on blood retinal barrier disruption 3 and 12 months after implantation of either a blue light filtering intraocular lens(blue-filtering IOL) or an ultraviolet light filtering intraocular lens(UV-filtering IOL).
The following parameters were measured for evaluation of blood retinal barrier disruption. * the incidence of macular leakage by fluorescence angiography (FA) * the mean fluorescein concentration in the vitreous by fluorophotometry (VFP) * the thickness of the macula by optical coherence tomography (OCT) Results * the incidence fo macular leakage decreased significantly from 24%(3 months) to 5% (12 months) in the blue-filtering IOL group (P\<0.05), and was significantly lower compared with the UV-filtering IOL group at 12 months. * the VFP significantly decreased in both group from 3 to 12 months. * the OCT decreased from 175 (3 months) to 166 um (12 months) in the blue- filtering IOL group.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
50
Intraocular lens implantation
Showa University Hospital
Tokyo, Tokyo, Japan
To measure FA, VEP and OCT.
Time frame: At 3 and 12 months after IOL implantation
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