Efficacy, Safety and Tolerability of AEB071 in Patients With Active, Moderate to Severe Ulcerative Colitis

Inclusion Criteria: * 18-75 years males and females * Female subjects of childbearing potential must be using two methods of contraception * Active, moderate to severe disease * Poor response to or no toleration of conventional therapy (e.g. steroids, mesalamine) * Good communication with the investigator, understanding and compliance with the requirements of the study and written informed consent Exclusion Criteria: * Allergy to the drug * Very low or high body weight * Ongoing treatment with specific other medication (e.g. antibiotics) * Diagnosis of primary sclerosing cholangitis * Renal impairment * Toxic megacolon * Presence or history of specific other diseases, cancer, cardiac abnormalities, abnormal laboratory findings * History of alcohol or drug abuse * Pregnant or breastfeeding women * Positive HIV, Hepatitis B or Hepatitis C test result Other protocol-defined inclusion/exclusion criteria do apply