To determine whether targeting lower arterial oxygen saturations from the day of birth alters the early (first 3 months) postnatal development of the control of ventilation and the hypercapnic and hyperoxic responses in very preterm infants.
To measure the effects of baseline oxygenation in extremely low birth weight preterm infants on: i) The early (first 5 breaths) and late or steady state (3-5 minutes) ventilatory response to CO2 ii) The immediate (\< 1 minute) ventilatory response to hyperoxia iii) The PCO2 apneic threshold iv) The breathing pattern during quiet and REM sleep v) The morphology of periodic breathing cycles vi) The incidence and morphology of sighs
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
26
Maintain functional oxygen saturation range between 91 and 95%
Maintain functional arterial oxygen saturations in the range of 85- 89%
St. Boniface General Hospital
Winnipeg, Manitoba, Canada
Health Science Centre
Winnipeg, Manitoba, Canada
Effects of targeting lower arterial oxygen saturations on the development of control of breathing in very preterm infants
Time frame: 3 months
To measure the effects of baseline oxygenation in extremely low birth weight preterm infants on the ventilatory response to CO2 and O2, the PCO2 apneic threshold, and the baseline breathing pattern
Time frame: 3 months
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