Open Label Trial of Fluoxetine for the Treatment of Depression in Patients With End Stage Renal Disease

Creighton University

Overview

The purpose of this study is to test whether once-weekly prozac therapy leads to reduction in depression in patients requiring kidney dialysis.

Once-weekly Prozac is a psychiatric medicine, approved by the FDA for the use in treatment of psychiatric disorders. This study will test whether once-weekly Prozac leads to reduced symptoms of depression. Patients requiring dialysis often report symptoms of depression either due to the presence of major depression, a relatively common psychiatric disorder, or due to depression secondary to kidney failure.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Conditions

Depression

Interventions

FluoxetineDRUG

Fluoxetine will be dosed at 90 mg once a week

Eligibility

Sex: ALLMin age: 19 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of chronic renal failure and end stage renal disease * Ongoing need for regular dialysis treatment * Diagnosis of depression based on DSMIV * Age tween 19-65 years Exclusion Criteria: * Inability to provide informed consent * Medically or psychiatrically unstable, as defined by requiring inpatient treatment * Pregnancy, nursing or refusal to use a reliable method of birth control in women * Patients with known allergy to fluoxetine, or previous treatment failure of fluoxetine

Locations (2)

Creighton Department of Psychiatry

Omaha, Nebraska, United States

Creighton University Department of Psychiatry

Omaha, Nebraska, United States

Outcomes

Primary Outcomes

Determine the efficacy and tolerability of once-weekly fluoxetine in patients with End Stage Renal Disorder who have been diagnosed with depression

Time frame: Patients will come in for once weekly visits for 12 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.