Prochlorperazine vs Imitrex for Acute Migraine in the Emergency Department

United States Naval Medical Center, Portsmouth

Overview

ED patients with acute migraine will be randomized to either prochlorperazine and Bendaryl OR imitrex. VAS for pain will be monitored, along with side effects. Primary outcome measure is improvement in pain scales between the groups.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Conditions

Acute Migraine Headache

Interventions

prochlorperazine and benadryl IVDRUG

prochlorperazine and benadryl IV, saline subQ

Imitrex SubQ, saline IVDRUG

Imitrex SubQ, saline IV

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Acute migraine headache Exclusion Criteria: * Pregnant * Hypertension * Chest pain * \< 18 * Allergy to any of the meds

Locations (1)

Naval Medical Center Portsmouth

Portsmouth, Virginia, United States

Outcomes

Primary Outcomes

Difference in pain measured by VAS

Time frame: 80 min

Secondary Outcomes

Degree of sedation, nausea, akathisia

Time frame: 80 min

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.