How Side Effects of Avonex Are Affected by Gradually Increasing to Full Dose vs Starting at Full Dose

Inclusion Criteria: * Diagnosis of clinically-definite relapsing-remitting multiple sclerosis Exclusion Criteria: * Any Product Information-specified contraindications to interferon-beta therapy, or other medical factors which, in the opinion of the investigator, make the subject unsuitable for interferon-beta therapy * Use of AVONEX, but not other interferon therapies, in the 3 months prior to randomisation into the study * A clinically significant infectious illness (e.g., cellulitis, abscess, pneumonia, septicemia) within 30 days prior to randomisation. * History of seizure in the 3 months prior to randomisation * History of suicidal ideation or severe depression within the 3 months prior to randomisation. * Other inclusion and exclusion criteria may apply per study protocol