In In vitro fertilization (IVF) treatment, poor responder patients of more than 38 years old are randomized prospectively into two dosages of gonadotrophins. The outcome of treatment will be analyzed.
Women \> 38 years, who had an insufficient response to stimulation with regular (for age) posology of 225 IU of gonadotrophins (urinary or recombinant), in an agonist protocol will be randomized prospectively into 2 groups: 300 IU versus 450 IU of Gonal-f® administered in a short agonist protocol. Insufficient response is defined as: development of ≤ 4 mature follicles (of ≥ 16 mm) at time of hCG administration. Patient can be eligible for several cycles in same protocol.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
400
Gonal-f®: follitropin alpha, administration of 300 U
Gonal-f®: follitropin alpha, administration of 450 U
CHC Saint-Vincent
Rocourt, Liège, Belgium
CHU Saint-Pierre
Brussels, Belgium
IMEC
Brussels, Belgium
UZ Gent
Ghent, Belgium
number of mature oocytes
Time frame: 1 month
follicular development
Time frame: 1 month
fertilization rate
Time frame: 1 month
implantation rate
Time frame: 1 month
embryo quality
Time frame: 1 month
pregnancy rate
Time frame: 1 month
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