Effects of Simvastatin on Biochemical Parameters and Outcome of IVF-ICSI in Pcos Patients

Tehran University of Medical Sciences120 enrolled

Overview

The purpose of this study is to determine whether simvastatin is effective in the improvement of IVF-ICSI outcome in Pcos patients.

simvastatin reduces cardiovascular risks by improving hypercholesterolemia, reducing vascular smooth muscle proliferation, ameliorating inflammation, limiting theca-interstitial proliferation \& decreasing steroidogenesis (production of progesterone \& testosterone).Polycystic ovary syndrome (pcos) is associated with increased cardiovascular risks and is characterized by ovarian theca-interstitial hyperplasia\& hyperandrogenism .This study will test the hypothesis that simvastatin improves biochemical parameters\& IVF-ICSI outcome in Pcos patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

DOUBLE

Enrollment

120

Conditions

Polycystic Ovary Syndrome

Interventions

SIMVASTATINDRUG

20 mg/day,po,for two months until the day of hCG injection placebo pills as like as simvastatin will be used

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Pcos patients * Age \<40 years * FSH\<10 IU/L Exclusion Criteria: * Endometriosis grade 3 \&4 * History of tubal surgery * Hydrosalpinx * History of mellitis diabetes

Locations (1)

Imam Khomeiny Hospital

Tehran, Iran

Outcomes

Primary Outcomes

ivf-et outcomes

Time frame: 14-20 days

Secondary Outcomes

Biochemical parameters baseline and 8weeks Biochemical parameters

Time frame: baseline and 8weeks

Data from ClinicalTrials.gov

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