Oral Vitamin D Supplementation in Elderly Women

University of Helsinki40 enrolled

Overview

The aim of this study is to compare oral vitamin D supplementation administered in two different ways, namely either twice a day (800IU/d, 292000IU/y) or three times a year (97333IU every 4 months, 292000IU/y) in elderly women in combination with daily supplementation of calcium 1 gram. We will 1)compare the blood concentrations of 25 OH vitamin D in the two treatment groups amd monitor if a sufficient and safe concentration of 25OH D in blood can be maintained with these two treatments.2) Find out seasonal variation in vitamin D concentrations in these treatments. 3) Find out safety of these treatments

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Optimal Vitamin D Administration

Interventions

vitamin D twice dailyDIETARY_SUPPLEMENT

Kalsipos-D, vitamin D3 400 ID/tbl, 2 tbl/day for one year

Vitamin D3 oil three times in a yearDIETARY_SUPPLEMENT

Vigantol oil , D3 20000IU/ml, 4.9 ml every four months for one year

Eligibility

Sex: FEMALEMin age: 70 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Females * 70-80 years * Living in the community Exclusion Criteria: * Renal disease * Diseases that contraindicate vitamin D supplementation * Medications affecting bone * Malignancy

Locations (1)

Helsinki University Central Hospital, department of medicine, division of endocrinology

Helsinki, Finland

Outcomes

Primary Outcomes

Blood 25 OH D vitamin concentrations

Time frame: 8 times during the year

Secondary Outcomes

serum calcium, 24-hour calcium excretion in urine, creatinine clearance

Time frame: 8 times during the year

Data from ClinicalTrials.gov

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