entGlycemic control has been found to improve clinical outcomes following Coronary Bypass Surgery. This study tests the hypothesis that obtaining tighter glycemic control(80-120mg/dl) as opposed to more moderate control (120-180mg/dl) will further improve outcomes.
150 diabetic patients will be randomized to achieve aggressive glycemic control (80-120mg/dl) vs moderate control (120-180mg/dl) using intravenous insulin infusions beginning at anesthetic induction and continuing for 18 hours following surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
108
IV insulin drip at 100units insulin in 100ml saline designed to keep blood glucose between 120-180mg/dl
IV insulin drip to keep serum glucose between 80-120mg/dl.
Boston Medical Center
Boston, Massachusetts, United States
Incidence of Hypoglycemia
Time frame: 24 hours following surgery
free fatty acid levels
Time frame: 24 hours following surgery
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