A Total Balanced Volume Replacement Regimen in Elderly Cardiac Surgery Patients

Klinikum Ludwigshafen50 enrolled

Overview

A total balanced fluid replacement strategy is a promising concept for correcting hypovolemia. The effects of a balanced fluid management including a new balanced hydroxyethylstarch (HES) in elderly cardiac surgery patients will be studied.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Elderly Cardiac Surgery

Interventions

Balanced HES 130/0.42DRUG

Volume is administered perioperatively and during the first 48 hrs after surgery when mean arterial pressure (MAP) was \<60mmHg and pulmonary capillary wedge pressure (PCWP) or central venous pressure (CVP) is \<10 mmHg

Balanced HES 130/0.42DRUG

Volume will be administered perioperatively and during the first 48 hrs after surgery when mean arterial pressure (MAP) is \<60mmHg and pulmonary capillary wedge pressure (PCWP) or central venous pressure (CVP) is \<10 mmHg

6% HES 130/0.4 prepared in saline solutionDRUG

Eligibility

Sex: ALLMin age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients aged \>80 years Exclusion Criteria: * Chronic kidney dysfunction requiring dialysis * Myocardial infarction within the previous 3 weeks * Liver insufficiency

Locations (1)

Klinikum Ludwigshafen

Ludwigshafen, RLP, Germany

Outcomes

Primary Outcomes

The primary endpoint of the study is postoperative renal function

Time frame: 28 days

Secondary Outcomes

Other organ function (myocardial function, endothelial function, degree of inflammation)

Time frame: Postoperative period

Data from ClinicalTrials.gov

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