A Study of a Topical Form of Nitroglycerin and Placebo in the Treatment and Prevention of Raynaud's Phenomenon

Inclusion Criteria: * Outpatients ages 15 - 70. * Patients with a diagnosis of Raynaud's phenomenon. * Patients who agree to apply study medication to their fingers. * Patients who are willing to stop current topical vasodilator therapies. * Patients who agree not to start or change dosage of current oral vasodilator therapies. * Patients who agree not to use any nitrate therapy while participating in this study. * Negative pregnancy test in fertile women and agreement to use effective contraception throughout the study. Exclusion Criteria: * Patients who currently use nitrate medication or medications known to interact with nitroglycerin. * Patients who have an allergy to nitroglycerin or common topical gel ingredients. * Patients with a history of severe headaches. * Patients with an unstable medical problem. * Patients with cognitive or language difficulties that would impair their ability to complete assessment of pain instruments. * Patients who have had a recent heart attack or other uncontrolled heart condition. * Patients who have participated in an investigational drug study within four weeks of visit one. * Patients who have clinically significant abnormal lab values. * Patients who have had recent major abdominal, thoracic or vascular surgery. * Patients with interfering skin conditions. * Pregnant or nursing women or women unwilling to comply with contraceptive requirements.