Rituximab in Rheumatoid Arthritis Lung Disease

Inclusion Criteria: 1. Diagnosis of RA according to the revised 1987 American Rheumatism Association criteria 2. Absence of clinical features suggesting infection, neoplasm, sarcoidosis, interstitial lung disease other than UIP or NSIP, other collagen vascular disease, or exposure to known fibrogenic drugs or environmental factors 3. Diagnosis of progressive interstitial pneumonia of UIP or NSIP subtype, based on the following criteria 1. Clinical symptoms consistent with interstitial lung disease with onset between 3 months and 36 months prior to screening. 2. Worsening as demonstrated by any one of the following within the past year: * \> 10% decrease in Forced Vital Capacity (FVC) * increasing infiltrates on chest X-ray or High Resolution Computed Tomography (HRCT), or worsening dyspnea at rest or on exertion 3. Diagnosis of UIP or NSIP by either of the following: * Open or video-assisted thoracic surgery (VATS) lung biopsy showing definite or probable UIP or NSIP * HRCT scan showing definite or probable UIP or NSIP AND abnormal pulmonary function tests (reduced FVC or decreased diffusing capacity of carbon monoxide (DLco) or impaired gas exchange at rest or with exercise) AND insidious onset of otherwise unexplained dyspnea or exertion and bibasilar, inspiratory crackles on auscultation 4. FVC \> 50% of predicted value at Screening 5. DLco \>30% of predicted value at Screening 5\. No change of disease-modifying anti-rheumatic drug (DMARD) treatment within the last 3 months Exclusion Criteria: 1. History of clinically significant environmental or drug exposure known to cause pulmonary fibrosis. 2. Forced expiratory volume in one second (FEV1) FEV1/FVC ratio \< 0.6 at screening (pre- or post-bronchodilator). 3. Residual volume \> 120% predicted at Screening 4. Evidence of active infection 5. Any pulmonary condition other than UIP/NSIP, which, in the opinion of the site principal investigator, is likely to result in the death of the patient within the next year 6. History of unstable or deteriorating cardiac or neurologic disease 7. Pregnancy or lactation 8. Treatment with cyclophosphamide, cyclosporine, interferon gamma or beta, anti-tumor necrosis factor therapy, anti-interleukin 1 (IL1) therapy or with endothelin receptor blockers within the last 8 weeks; experimental therapy for rheumatoid arthritis 9. Creatinine \> 1.5 X upper limit of normal range (ULN) at Screening 10. Hematology outside of specified limits: white blood cell (WBC) \< 2,500/mm\^3 or absolute neutrophil count (ANC) \< 1500 11. Hematocrit \< 27% or \> 59%, platelets \< 100,000/mm\^3 at screening 12. Positive hepatitis B or C serology 13. Any medical condition, which in the opinion of the site principal investigator, may be adversely affected by the participation in this study 14. History of recurrent significant infection or history of recurrent bacterial infections 15. Known active bacterial, viral fungal mycobacterial, or other infection (including tuberculosis or atypical mycobacterial disease, but excluding fungal infections of nail beds) or any major episode of infection requiring hospitalization or treatment with i.v. antibiotics within 4 weeks of screening or oral antibiotics within 2 weeks prior to screening 16. Abnormal neurological examination reflective of central nervous disease, including paresis, cognitive impairment and problems with coordination 17. Current enrollment in another clinical trial 18. Fever (\>99.5º F) 19. History of previous rituximab administration 20. Receipt of any vaccine, particularly live viral vaccines, within 4 weeks of first study dose 21. Decreased Immunoglobulin G (IgG) and Immunoglobulin M (IgM) levels (below lower limit of normal range) 22. Present or past malignancy 23. History of severe allergic or anaphylactic reaction to administration of humanized or murine monoclonal antibodies 24. Positive human immunodeficiency virus (HIV) serology