NCT00579241 - Detection of Ultrasound Contrast Signals in the Cerebral Circulation | Crick

Overview

To Determine whether transcranial ultrasound can detect the presence of intravenously injected microbubbles used routinely for dobutamine stress echocardiography.

The purpose of this study is to determine whether the intravenous microbubbles used to improve border delineation during dobutamine stress echocardiographies (DSE) can be detected within the cerebral circulation.

Study Type

INTERVENTIONAL

Allocation

NA

Purpose

DIAGNOSTIC

Masking

NONE

Conditions

Brain Vascular Disorders Coronary Artery Disease

Interventions

Ultrasound on Temporal BonePROCEDURE

All Patients undergoing dobutamine stress echocardiography have an intravenous line placed and a continuous infusion of a commercially available contrast agent administered. Prior to contrast infusion, baseline transcranial ultrasound images at 0.4 mechanical index using low mechanical index pulses and color Doppler will be performed and recorded. After this the contrast infusion will begin, and resting cardiac images will occur.

Eligibility

Sex: ALLMin age: 19 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * male or female age \>19 years of age * scheduled for a stress echocardiogram * negative urine pregnancy test within two hours of ultrasound contrast administration required for females of childbearing age unless post-menopausal or with evidence of surgical sterilization * be conscious and coherent, and able to communicate effectively with trial personnel Exclusion Criteria: * pregnant or lactation * life expectancy of less than 2 months or terminally ill * Known or suspected hypersensitivity to ultrasound contrast agent used for the study * complicated hemodynamic instability * Known left main disease

Outcomes

Primary Outcomes

Detect abnormalities in cerebral blood flow

All Patients undergoing dobutamine stress echocardiography have an intravenous line placed and a continuous infusion of a commercially available contrast agent administered. Prior to contrast infusion, baseline transcranial ultrasound images at 0.4 mechanical index using low mechanical index pulses and color Doppler will be performed and recorded. After this the contrast infusion will begin, and resting cardiac images will occur.

Time frame: immediate

Secondary Outcomes

if cerebral vascular disease is detected it would lead to further testing that may better identify abnormalities.

All Patients undergoing dobutamine stress echocardiography have an intravenous line placed and a continuous infusion of a commercially available contrast agent administered. Prior to contrast infusion, baseline transcranial ultrasound images at 0.4 mechanical index using low mechanical index pulses and color Doppler will be performed and recorded. After this the contrast infusion will begin, and resting cardiac images will occur.

Time frame: within 30 minutes