In this study the investigators propose to assess the hemodynamic response to the ingestion of 16 fl oz of water. The investigators will test the hypothesis that water ingestion will increase the systemic vascular resistance.
In this study we propose to assess the hemodynamic response to the ingestion of 16 fl oz of water. We will test the hypothesis that water ingestion will increase the systemic vascular resistance. This study will occur in patients status post cardiac transplantation during their clinical right heart catheterizations. Invasive hemodynamics including cardiac outputs and plasma norepinephrine levels will be measured before and 30 min after the water ingestion.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
40
water 500 ml x 1
Tennessee Valley Health Systems (Nashville VA)
Nashville, Tennessee, United States
Vanderbilt University
Nashville, Tennessee, United States
change in total vascular resistance
TPR measured by Modelflow
Time frame: 40 min (before to 30 min after water ingestion
blood pressure
peak BP over 40 min
Time frame: 40 min
heart rate
HR at time of peak BP over 40 min
Time frame: 40 min
plasma norepinephrine
plasma norepinephrine drawn 40 min post ingestion
Time frame: 40 minutes
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