80 nicotine dependent adults ages 18-65 who desire to quit smoking will be screened and, if eligible, enrolled and randomized to one of two four-week treatments for smoking cessation. The treatments are standard behavioral therapy and Mindfulness Based Addiction Therapy (MBAT), which is standard therapy plus mindfulness. Standard therapy and MBAT incorporate elements of widely-used tools for smoking cessation including managing craving and strong emotions, problem solving, tips on healthy eating and keeping active, and exercises based on cognitive and behavioral therapy. MBAT uniquely incorporates mindfulness practice (a relaxation therapy) into standard therapy. Participants complete questionnaires and undergo an fMRI scan at baseline and at the end of therapy (after they complete the 4 weeks of standard therapy or MBAT). During each scan, participants will complete a validated smoking-related cue paradigm and a validated affect labeling paradigm.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
79
Standard therapy to help participants with smoking cessation.
A novel mind body therapy that extends basic behavioral therapy principles to include the practice of mindfulness, which fosters a dispassionate approach to the experience of craving.
University of Pittsburgh
Pittsburgh, Pennsylvania, United States
Smoking Cessation
Time frame: week 2 and 6 month follow-up
Exhaled CO readings
Time frame: baseline, weeks 2-4, post class follow-up, long term follow-up
Saliva Test
Time frame: baseline
Functional Magnetic Resonance Imaging
Time frame: baseline & follow-up
Urine Pregnancy Test
Time frame: baseline & follow-up
Nicotine Replacement Therapy
Time frame: Week 1
Self Reported Measures
Time frame: baseline, post class follow-up & long term follow-up
Standard Cognitive Therapy
Time frame: weeks 1-4
Mindfulness Based Cognitive Therapy
Time frame: weeks 1-4
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