Phase II Study of Adenovirus/PSA Vaccine in Men With Hormone - Refractory Prostate Cancer

Inclusion criteria: * Men with prostate cancer who present with evidence of hormone refractory disease (D3). * Men with a positive bone scan or a positive CT scan (with obvious soft tissue metastasis or lymph nodes \>1 cm), a PSA doubling time of \>/= 6 months, and a total PSA of \<10 ng/ml, and asymptomatic OR men with a negative bone scan and a negative CT scan with any PSA doubling time and asymptomatic. * Scans must be obtained within 6 weeks of initiation of treatment. * Written informed consent. * Age \>/= 18 years. * Required laboratory values (obtained within 2 weeks of initiation of treatment) * Serum creatinine \</= 2.0 mg/dL * Adequate hematologic function: granulocytes \>/= 1800 per mm3, platelets \>/= 100,000 per mm3, WBC \>/= 3700, and lymphocytes \>590. * Adequate hepatocellular function: AST \<3x upper limit of normal and total bilirubin \<1.5 mg/dl (unless bilirubin elevation is consistent with Gilbert's syndrome). * Castrate levels of testosterone of \</= 50 ng/ml. * PSA can be used as an eligibility criterion must be drawn within 28 days prior to injection number 1 and will be drawn on Day 1 for use as a baseline value. Exclusion criteria: * Active or unresolved clinically significant infection. * Parenteral antibiotics \<7 days prior to initiation of treatment. * Evidence of prior or current CNS metastases. Specific imaging is not necessary in the absence of signs or symptoms. * Co-morbid medical conditions which would result in a life expectancy (participation) of less than 1 year. * Patients with compromised immune systems; congenital, acquired, or drug-induced (immunosuppressive agents) will be excluded from the study. Use of prednisone at doses higher than 10 mg daily (or equipotent steroid doses) for more than 7 days within 3 months of initiation of treatment is not allowed. * Pre-existing malignancies that required treatment within the past 5 years except for basal or squamous cell cancers of the skin. * Prior participation in any vaccine studies for non-infectious diseases. * Prior chemotherapy, defined as prior cytotoxic chemotherapy for prostate cancer (or any cancer unless more than 5 years have elapsed). Examples of cytotoxic chemotherapy are mitoxantrone/prednisone and taxanes. Drugs such as Casodex or ketoconazole treatment must have been completed at least 6 weeks prior to initiation of treatment. * The inability to understand the language and the clinical protocol. * Allergy or religious objection to pork products; Gelfoam is produced from pork.