Open-Label Duloxetine Monotherapy in the Treatment of Posttraumatic Stress Disorder

Inclusion Criteria: * Male or female patients ages 18 or older of any ethnic background meeting DSM-IV criteria for PTSD * Score of at least 60 on the CAPS-SX at baseline * Competent to give informed consent * If female, patient should be using a medically approved contraceptive, or not otherwise be of childbearing potential * Patients who have not taken medications or herbal remedies for a psychiatric indication within one week prior to the baseline visit (treatment phase); two weeks prior in the case of fluoxetine or in the case of an MAOI * Other medications, if any, must have been kept stable for at least one month prior to the baseline visit Exclusion Criteria: * Known hypersensitivity to duloxetine or any of the inactive ingredients * Females who are pregnant or breastfeeding * Use of antipsychotics, antidepressants, or benzodiazepines (except for short-term use during study as specified in Concomitant Medications section) within one week prior to the baseline visit and throughout the study period * Use of fluoxetine or an MAOI within two weeks * Concomitant use of narrow therapeutic index medications or medications that are likely to have a clinically significant drug interaction with duloxetine * Medical conditions that may prevent safe administration of duloxetine including end stage renal disease, clinically significant renal impairment (CrCl \<30 mL/min), hepatic insufficiency, cardiac disease, or pulmonary disease * Patients with uncontrolled narrow-angle glaucoma * Alcohol or drug abuse or dependence within three months of study entry as defined by DSM-IV criteria * Alcohol use may not exceed 12 drinks per week or 5 drinks per drinking episode during the course of the study. * A current or past history of bipolar disorder, schizophrenia, schizoaffective disorder or other psychotic disorder * Suicidal or homicidal ideation or other clinically significant dangerous behavior * Currently seeking compensation or increase in compensation for the effects of the trauma * Initiation or change in psychotherapy within 3 months of study entry